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Topical application of P-selectin monoclonal antibody alters leukocyte rolling in rat mesenteric venules.
The effect of topical application of the monoclonal antibody (MoAb) P-selectin on leukocyte rolling in the mesenteric venules of anaesthetized rats was investigated by means of in vivo microscopy. The site-specific application of 20 micrograms of MoAb P-selectin to the venular wall, in a dose sufficient to completely block P-selectin expression, led to a remarkable reduction in rolling leukocytes when compared with control venules or venules in which MoAb P-selectin was not applied. The rolling velocity was decreased to about 50% of the baseline level within 15 min after MoAb P-selectin treatment, but returned to the baseline level within 2 h. By contrast, similar application of MoAb G-selectin had no effect on leukocyte rolling. These results suggest that the topically applied MoAb P-selectin on the surface of venular endothelium influences the rolling behavior of blood leukocytes.Neuroendocrine changes during a myocardial infarction.
To study the neuroendocrine changes after a myocardial infarction (MI), aortic and superior mesenteric artery perfusion was studied in six dogs. Autoregulation of the aorta was evident in all animals during constant left atrial pressure (LAP) in the range of 3.5-6.5 mmHg. The values for total a

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Methanotrophs are a type of archaea that produce methane. This is their only known metabolic function, but they do have other roles within the archaea domain. These roles include serving as the host for other organisms and as a reservoir of carbon for the community. They are obligate anaerobes, which means that they can only function in the absence of oxygen. They are also the only known living organisms to produce methane in an environment where carbon is not limiting.

Methanotrophs were first isolated and studied by Alexander Fleming and A.J. Milner in 1952. Their first role as a carbon sink was described by Roger J. Crow and Robert F. Young in 1967.


Methanotrophs can be distinguished from other archaeal groups based on the following characteristics:
the presence of a membrane with enzymes that split the bonds between carbon and nitrogen, such as α-ketoglutarate-dependent dioxygenases. This process generates molecular hydrogen, which is used to produce methane, the main component of natural gas.
their use of an N-rich coenzyme M, called S-coenzyme M, to synthesize methane in place of N-rich coenzyme Q. This coenzyme is distinct from S-coenzyme Q, the only coenzyme other than N-rich coenzyme Q that is known to be used in methane biosynthesis by methanogens.
their use of the enzyme methanol dehydrogenase to oxidize methanol and reduce molecular hydrogen to methane.

The ability to oxidize methane is a defining feature of methanotrophic archaea.

Methanotrophs are found in a wide variety of terrestrial, marine, and freshwater environments. They are known to dominate in environments where there is a high concentration of methane.


Category:Energy metabolism
Category:Metabolic pathwaysIn the realm of digital information, there are two main techniques for storage and transport of the digital information—serial and parallel. For serial transmission, digital information is represented by a series of different voltages and the receiver is generally set up to detect each voltage, one at a time.

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